Your Trusted Partner for Quality Raw Pretomanid Powder & API Supply
We understand the demanding quality and regulatory standards of the pharmaceutical industry. That’s why we ensure every batch of our Raw Pretomanid powder for suppliers meets stringent pharmacopeial guidelines for purity, stability, and efficacy.
Industries We Serve
Pharmaceutical Manufacturers
Research & Development Labs
Hospitals & Healthcare Institutions
Contract Manufacturing Organizations (CMOs)
About the Raw Material: Application & Mechanism
Pretomanid is a vital Active Pharmaceutical Ingredient (API) and a cornerstone of the world's most effective short-course regimen for highly drug-resistant tuberculosis.
Primary Application
Pretomanid API is specifically utilized in the manufacture of finished drug formulations indicated for the treatment of Pulmonary Extensively Drug-Resistant (XDR-TB) and Multidrug-Resistant (MDR-TB) in adults who are treatment-intolerant or non-responsive to standard therapy.
It is typically administered as part of a triple-drug, all-oral combination regimen with Bedaquiline and Linezolid (BPaL regimen).
Mechanism of Action (MoA)
Pretomanid is a prodrug that is activated inside Mycobacterium tuberculosis cells by the Ddn nitroreductase enzyme. Its potent bactericidal activity targets both active and non-replicating bacteria through a dual mechanism:
- Inhibition of Cell Wall Synthesis: In actively replicating cells, it blocks the biosynthesis of mycolic acids, a crucial component of the mycobacterial cell wall.
- Respiratory Poison: In non-replicating (dormant) cells, it generates reactive nitrogen species (like nitric oxide), effectively acting as a respiratory poison.
The result is potent activity against even highly resistant strains of M. tuberculosis.
Packaging, Storage & Logistics
As your trusted import partner, Chennai Pharma manages the complex logistics of this critical API from source to your manufacturing unit.
Packaging Details
- Standard Unit: HDPE Drums (available in 5 kg, 10 kg, and 25 kg net weights).
- Inner Packaging: Double Polyethylene (PE) bags, heat-sealed, ensuring moisture and light protection.
- Labeling: Complies with all GHS (Globally Harmonized System) and local (CDSCO/Customs) labeling requirements.
Storage & Stability
- Recommended Storage: Store at 9$2^\circ\text{C}$ to 10$8^\circ\text{C}$ (Refrigerator) or per COA, in a tightly sealed container.11
- Protection: Protect from direct light, excessive heat, and moisture.
- Shelf Life: Minimum [X] Months under recommended storage conditions (Exact date on COA).
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